LL-37 Dosage Calculator: Reconstitution and Units

To calculate an LL-37 dose, divide vial mg by BAC water mL for concentration (mg/mL), divide your target dose by concentration for draw volume (mL), then multiply by 100 for U-100 units. LL-37 doses are typically 50–250 mcg per administration.

Example LL-37 Dosage Table

Common vial and BAC water combinations with calculated concentration, draw volume, and U-100 syringe units. For education only — verify your vial label before use.

Vial (mg)	BAC water (mL)	Concentration	Dose (mg)	Draw (mL)	U-100 units
5 mg	2 mL	2.5 mg/mL	0.05 mg	0.02 mL	2 units
5 mg	2 mL	2.5 mg/mL	0.1 mg	0.04 mL	4 units
5 mg	2 mL	2.5 mg/mL	0.25 mg	0.1 mL	10 units
10 mg	5 mL	2 mg/mL	0.1 mg	0.05 mL	5 units

How to Calculate LL-37 Dosage

Three steps convert any vial and BAC water combination into the exact volume to draw on a U-100 insulin syringe.

Step 1 — Calculate concentration (mg/mL)
Divide the total peptide in the vial (mg) by the volume of BAC water you added (mL). For example: a 5 mg LL-37 vial reconstituted with 2 mL BAC water gives 5 ÷ 2 = 2.5 mg/mL.
Step 2 — Calculate draw volume (mL)
Divide your target dose (mg) by the concentration (mg/mL). For a 0.5 mg dose at 2.5 mg/mL: 0.5 ÷ 2.5 = 0.2 mL. This is the exact volume to draw into the syringe.
Step 3 — Convert to U-100 syringe units
Multiply the draw volume (mL) by 100. For 0.2 mL: 0.2 × 100 = 20 U-100 units. Read this number on the unit markings of a standard insulin syringe.

Dosage Formula

Concentration formula

Concentration (mg/mL) = Vial mg ÷ BAC water mL

Draw volume formula

Draw volume (mL) = Dose (mg) ÷ Concentration (mg/mL)

U-100 syringe units

U-100 units = Draw volume (mL) × 100

These three formulas apply to any LL-37 vial, regardless of size. U-100 is the standard insulin-syringe scale: 100 units = 1 mL.

LL-37 Calculator Tool

Enter your vial strength, BAC water volume, and target dose below. The calculator outputs concentration (mg/mL), draw volume (mL), and U-100 units. Educational and research use only.

Example LL-37 Calculations

Step-by-step worked examples using common vial sizes. Results are for illustrating the math only.

5 mg vial + 2 mL BAC + 100 mcg (0.1 mg) dose

Vial: 5 mg | BAC water: 2 mL | Target dose: 0.1 mg
Concentration: 5 ÷ 2 = 2.5 mg/mL
Draw volume: 0.1 ÷ 2.5 = 0.04 mL
U-100 units: 0.04 × 100 = 4 units

10 mg vial + 5 mL BAC + 250 mcg (0.25 mg) dose

Vial: 10 mg | BAC water: 5 mL | Target dose: 0.25 mg
Concentration: 10 ÷ 5 = 2 mg/mL
Draw volume: 0.25 ÷ 2 = 0.125 mL
U-100 units: 0.125 × 100 = 12.5 units

LL-37 Reconstitution Guide

LL-37 (cathelicidin) is supplied as a lyophilized powder in 5 mg or 10 mg vials.

Add BAC water slowly along the vial wall. Swirl gently — do not shake.
Common setup: 5 mg vial + 2 mL BAC = 2.5 mg/mL. Each 0.1 mg (100 mcg) dose = 0.04 mL = 4 units.
Refrigerate at 2–8 °C once reconstituted. Use within 3–4 weeks.

Frequently Asked Questions

What is LL-37?

LL-37 is the only human cathelicidin antimicrobial peptide. It is studied for broad-spectrum antimicrobial activity and immune-modulating properties in research models.

How does LL-37 relate to immune defense?

LL-37 is part of the innate immune system, expressed in epithelial cells, neutrophils, and macrophages. Research focuses on its antimicrobial, wound-healing, and immunomodulatory roles.

What are U-100 syringe units?

U-100 is the standard scale for insulin syringes. 100 units = 1.0 mL. That means 10 units = 0.1 mL, 50 units = 0.5 mL. Multiply any draw volume in mL by 100 to get the U-100 units reading.

Do I need to recalculate if I change the amount of BAC water?

Yes. Changing BAC water volume changes the concentration (mg/mL), which changes the draw volume for the same mg dose. Always recalculate using: concentration = vial mg ÷ BAC water mL, then draw volume = dose mg ÷ concentration.

How do I convert mcg to mg for the calculator?

Divide mcg by 1000 to get mg. For example: 250 mcg = 0.25 mg, 500 mcg = 0.5 mg, 1000 mcg = 1 mg. Enter the mg value in the calculator.

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For educational and research purposes only. Not medical advice. Consult a licensed healthcare professional before making any medical or health-related decisions.