5-Amino-1MQ Peptide Guide

5-Amino-1MQ is a synthetic small molecule that targets NNMT (nicotinamide N-methyltransferase). NNMT sits at a crossroads between NAD+ biology (energy and repair signaling) and methyl donor balance (SAM/SAH). When NNMT activity is high in fat tissue in some obesity models, it can shift metabolite pools toward fat storage.

Educational information only. Not medical advice.

• Preclinical: reduced fat mass and body weight in obesity models
• Preclinical: increased intracellular NAD+ and SAM pools reported in experiments

Primary pathways (studied):

• NNMT-mediated nicotinamide methylation (nicotinamide + SAM → 1-MNA + SAH)
• NAD+ salvage pathway (indirect)
• Methionine cycle and methylation potential (SAM/SAH balance)
• Adipocyte lipid metabolism (lipogenesis and storage programs)

Cell-level effects (studied):

• Direct inhibition of NNMT enzymatic activity
• Lower intracellular 1-MNA production
• Higher intracellular NAD+ pools reported in preclinical work
• Reduced lipogenesis in cultured adipocytes

System-level effects (studied):

• Reduced body weight and white adipose tissue mass in obese mice (preclinical)
• Smaller adipocyte size in mouse models (preclinical)
• Effects appear not primarily driven by appetite suppression in key mouse studies (preclinical)

Half-life: Not fully established

Duration: Not fully established

Peak time: Not fully established

Storage depends on formulation (lyophilized powder vs reconstituted solution) and the manufacturer. Follow the product label when available.

• Dry / lyophilized: commonly kept cool, dry, and protected from light.
• Reconstituted: commonly refrigerated and used within the supplier’s stated window.
• Avoid: repeated heat exposure and unnecessary freeze–thaw cycles.

For measurement math (mg, mL, and U-100 units), use:

• Peptide reconstitution guide
• Peptide reconstitution calculator

Protocol pages summarize common research-style structures and measurement concepts. They do not provide individualized instructions.

Educational information only. Not medical advice.

Key research takeaways surfaced on this page

• Research context available in the underlying profile.
• Research context available in the underlying profile.

Primary references and supporting sources

• Nicotinamide N-methyltransferase inhibition mitigates obesity-related metabolic dysfunction — Recent 5A1MQ preclinical paper covering obesity, glucose, and liver outcomes.
• Nicotinamide N-methyltransferase (NNMT): a novel therapeutic target for metabolic syndrome — Review article that explains the rationale for targeting NNMT in metabolic research.