5-Amino-1MQ Peptide Guide
Research-based overview of 5-Amino-1MQ and NNMT inhibition. This page covers key concepts around 5-amino-1mq, with links to dosage calculators, protocols, and comparison guides where relevant. PeptideUniv provides interactive tools and structured content for research and education only; we do not provide medical advice.
What is 5-Amino-1MQ?
5-Amino-1MQ is a synthetic small molecule that targets NNMT (nicotinamide N-methyltransferase). NNMT sits at a crossroads between NAD+ biology (energy and repair signaling) and methyl donor balance (SAM/SAH). When NNMT activity is high in fat tissue in some obesity models, it can shift metabolite pools toward fat storage.
Educational information only. Not medical advice.
Benefits
- Preclinical: reduced fat mass and body weight in obesity models
- Preclinical: increased intracellular NAD+ and SAM pools reported in experiments
Mechanism of action
Primary pathways (studied):
- NNMT-mediated nicotinamide methylation (nicotinamide + SAM → 1-MNA + SAH)
- NAD+ salvage pathway (indirect)
- Methionine cycle and methylation potential (SAM/SAH balance)
- Adipocyte lipid metabolism (lipogenesis and storage programs)
Cell-level effects (studied):
- Direct inhibition of NNMT enzymatic activity
- Lower intracellular 1-MNA production
- Higher intracellular NAD+ pools reported in preclinical work
- Reduced lipogenesis in cultured adipocytes
System-level effects (studied):
- Reduced body weight and white adipose tissue mass in obese mice (preclinical)
- Smaller adipocyte size in mouse models (preclinical)
- Effects appear not primarily driven by appetite suppression in key mouse studies (preclinical)
Half-life
Half-life: Not fully established
Duration: Not fully established
Peak time: Not fully established
Storage
Storage depends on formulation (lyophilized powder vs reconstituted solution) and the manufacturer. Follow the product label when available.
- Dry / lyophilized: commonly kept cool, dry, and protected from light.
- Reconstituted: commonly refrigerated and used within the supplier’s stated window.
- Avoid: repeated heat exposure and unnecessary freeze–thaw cycles.
Reconstitution guide
For measurement math (mg, mL, and U-100 units), use:
Protocol overview
Protocol pages summarize common research-style structures and measurement concepts. They do not provide individualized instructions.
Educational information only. Not medical advice.
Research review and sources
Key research takeaways surfaced on this page
- Research context available in the underlying profile.
- Research context available in the underlying profile.
Primary references and supporting sources
- Nicotinamide N-methyltransferase inhibition mitigates obesity-related metabolic dysfunction — Recent 5A1MQ preclinical paper covering obesity, glucose, and liver outcomes.
- Nicotinamide N-methyltransferase (NNMT): a novel therapeutic target for metabolic syndrome — Review article that explains the rationale for targeting NNMT in metabolic research.
Dosage and calculator
Suggested links
For educational and research purposes only. Not medical advice. Consult a licensed healthcare professional for personal guidance.